Urocortin III (human)

Description

Urocortin III human is a corticotropin-releasing factor CRF -related peptide. Urocortin III human preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III human potently binds to type 2 CRF receptors, specifically mCRF2? Ki = 13.5 nM and rCRF2? Ki = 21.7 nM , while demonstrating negligible affinity for hCRF1 Ki 100 nM. Urocortin III human mediates somatostatin-dependent negative feedback control of Insulin human HY-P0035 secretion 1 2 .