GENERAL CATALOGUE
USP1-IN-11
HY-170921 · 50 mg
MedChemExpress · Cat: HY-170921
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Manufacturer product page
medchemexpress.com/usp1-in-11.htmlCatalog No: HY-170921
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
USP1-IN-11 compound 38-P2 is a selective, reversible, and noncompetitive USP1 Ubiquitin-specific protease 1 inhibitor. USP1-IN-11 activates the DDR DNA damage repair pathway, induces cell cycle arrest and cell Apoptosis, and inhibits cell survival. USP1-IN-11 enhances the sensitivity of Olaparib HY-10162 -resistant cells to Olaparib HY-10162 and shows a synergetic effect with Andrographolide HY-N0191 in BRCA-proficient cancer cells. USP1-IN-11 displays significant, dose-dependent antitumor efficacy in the MDA-MB-436 xenograft model.
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