GENERAL CATALOGUE
USP1-IN-9
HY-162633 · 50 mg
MedChemExpress · Cat: HY-162633
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medchemexpress.com/usp1-in-9.htmlCatalog No: HY-162633
CAS No: 2925548-22-5
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
USP1-IN-9 Compound 1m is reversible and noncompetitive ubiquitin-specific proteases USP1 inhibitors with an IC50 of 8.8 nM, which is designed and synthesized to pyrido 2,3-d pyrimidin-7 8H -one derivative based on the disclosed structure of ML323 HY-17543 and KSQ-4279 HY-145471 . USP1-IN-9 displays excellent USP1/UAF inhibition and exhibits strong antiproliferation effect in breast cancer cells. USP1-IN-9 can generate enhanced cell killing with PARP inhibitor olaparib HY-10162 in olaparib-resistant MDA-MB-436/OP cells, which is promising for research in the field of cancer.
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