GENERAL CATALOGUE
USP5-IN-1
HY-139979 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-139979
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medchemexpress.com/usp5-in-1.htmlCatalog No: HY-139979
CAS No: 2851040-81-6
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
USP5-IN-1 compound 64 is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain ZnF-UBD KD=2.8 ?M . USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers.
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