Valproic acid-d4 sodium

Description

Valproic acid-d4 sodium is the deuterium labeled Valproic acid. Valproic acid VPA; 2-Propylpentanoic Acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 IC50, 400 ?M , and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer SCLC cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.