VAV1 Mouse Monoclonal Antibody

Description

EnkiLife offers the VAV1 Mouse Monoclonal Antibody. This antibody reacts with Human species and is suitable for WB,ELISA,FC application. Alternative Names of Immunogen: VAV. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:250-1:1000,ELISA 1:5000-1:20000,FC 1:200-1:400 Background: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.