GENERAL CATALOGUE
VCP/p97 IN-3
HY-174984 · 50 mg
MedChemExpress · Cat: HY-174984
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Manufacturer product page
medchemexpress.com/vcp-p97-in-3.htmlCatalog No: HY-174984
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
VCP/p97 IN-3 is a VCP/p97 allosteric inhibitor. VCP/p97 IN-3 shows the inhibitory activity against the VCP proteins with an IC50 of 9 nM and the mutant VCP proteins with IC50 of 12 nM N660K and 19 nM V474A/D649A . VCP/p97 IN-3 increases K48-linked ubiquitination and the level of cleaved caspase-3. VCP/p97 IN-3 activates ER-stress and the UPR. VCP/p97 IN-3 inhibits tumor growth in RPMI-8226 cell subcutaneous xenograft mouse models. VCP/p97 IN-3 can be used for the study of multiple myeloma.