VEGFR-2/DHFR-IN-1

Description

VEGFR-2/DHFR-IN-1 compound 8b is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.384 and 7.881 ?M, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 ?g/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 2.97-7.12 ?M. VEGFR-2/DHFR-IN-1 can be used for the research of cancer.