GENERAL CATALOGUE
Vercirnon sodium
HY-15724A · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-15724A
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Catalog No: HY-15724A
CAS No: 886214-18-2
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Vercirnon GSK1605786A sodium is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon sodium inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 IC50s 10 ?M for all. Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 CCR9A and CCR9B with IC50 values of 2.8 and 2.6 nM, respectively.
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