Vercirnon sodium (Standard)

Description

Vercirnon sodium Standard is the analytical standard of Vercirnon sodium . This product is intended for research and analytical applications. Vercirnon GSK1605786A sodium is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon sodium inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 IC50s 10 ?M for all. Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 CCR9A and CCR9B with IC50 values of 2.8 and 2.6 nM, respectively.