GENERAL CATALOGUE
Vercirnon (Standard)
HY-15724R · 1 mg
MedChemExpress · Cat: HY-15724R
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medchemexpress.com/vercirnon-standard.htmlCatalog No: HY-15724R
CAS No: 698394-73-9
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
Vercirnon Standard is the analytical standard of Vercirnon. This product is intended for research and analytical applications. Vercirnon GSK1605786A is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 IC50s 10 ?M for all. Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 CCR9A and CCR9B with IC50 values of 2.8 and 2.6 nM, respectively.