GENERAL CATALOGUE
VLS-1272
HY-153066 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-153066
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medchemexpress.com/kif18a-in-7.htmlCatalog No: HY-153066
CAS No: 2914878-00-3
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
VLS-1272 Compound 22 is an orally active KIF18A inhibitor that binds to the KIF18A-microtubule complex in an ATP-noncompetitive manner IC50 = 41 nM , blocking its ATPase activity and inhibiting microtubule translocation. This leads to abnormal accumulation of KIF18A at spindle poles, disrupting chromosome alignment and inducing mitotic arrest and apoptosis in CINHigh tumor cells e.g., ovarian cancer OVCAR-3, breast cancer JIMT-1 . VLS-1272 is a promising candidate for anti-tumor research.
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