GENERAL CATALOGUE
Volasertib trihydrochloride
HY-12137A · 50 mg
MedChemExpress · Cat: HY-12137A
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medchemexpress.com/volasertib-trihydrochloride.htmlCatalog No: HY-12137A
CAS No: 946161-17-7
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
Volasertib BI 6727 trihydrochloride is an orally active, highly potent and ATP-competitive Polo-like kinase 1 PLK1 inhibitor with an IC50 of 0.87 nM. Volasertib trihydrochloride inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib trihydrochloride induces mitotic arrest and apoptosis. Volasertib trihydrochloride, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models.
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