VS1150

Description

VS1150 Compound 11 is a BCR-ABL-targeting phosphorylation-inducing chimeric small molecule PHICS . VS1150 significantly inhibits oncogenic kinase BCR-ABL signaling by inducing inhibitory phosphorylation at its Y253 EC50: 69 nM , subsequently triggering cell apoptosis. VS1150 also inhibits other oncogenic ABL fusions and drug-resistant mutants like T315I. VS1150 can be used for chronic myeloid leukemia CML and other ABL fusion-driven cancers research.