GENERAL CATALOGUE
VU0360172
HY-120589 · 5 mg
MedChemExpress · Cat: HY-120589
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Catalog No: HY-120589
CAS No: 1310012-12-4
Category: GPCR G Protein
Pack Size: 5 mg
Brand: MedChemExpress
Description
VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide PI hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice. VU0360172 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition CuAAc with molecules containing Azide groups.
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