GENERAL CATALOGUE
VU0364770
HY-100588 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-100588
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Catalog No: HY-100588
CAS No: 61350-00-3
Category: GPCR G Protein
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
VU0364770 is a selective and potent positive allosteric modulator PAM of mGlu4. VU0346770 exhibits EC50s of 290 nM and 1.1 ?M at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 exhibits antagonist activity at mGlu5 with a potency of 17.9 ?M and PAM activity at mGlu6 with a potency of 6.8 ?M. VU0364770 also possesses activity at MAO with Ki values of 8.5 and 0.72 ?M for human MAO-A and human MAO-B, respectively.
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