GENERAL CATALOGUE
VU0467319
HY-173396 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-173396
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medchemexpress.com/vu0467319.htmlCatalog No: HY-173396
CAS No: 1432438-14-6
Category: GPCR G Protein
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
VU0467319 Compound VU319 is a highly selective and blood-brain-permeable, orally active M1 positive allosteric modulator PAM EC50: 492 nM . VU0467319 is selective EC50 30 ?M versus M2-5 for both human and rat. VU0467319 improves cognitive impairment in Alzheimers disease AD through central M1 muscarinic receptors. VU0467319 does not induce cholinergic adverse reactions and has potential in AD research.
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