GENERAL CATALOGUE
VU0467485
HY-120184 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-120184
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Catalog No: HY-120184
CAS No: 1451994-10-7
Category: GPCR G Protein
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
VU0467485 AZ13713945 is a potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 M4 positive allosteric modulator PAM . VU0467485 AZ13713945 potentiates activity of ACh at M4 with EC50s of 26.6 nM and 78.8 nM at rat and human M4 receptors, respectively. VU0467485 AZ13713945 shows selectivity for M4 over human and rat M1/2/3/5. VU0467485 AZ13713945 displays moderate to high CNS penetration. VU0467485 AZ13713945 has antipsychotic-like activity.
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