GENERAL CATALOGUE
VU6033685
HY-173032 · 50 mg
MedChemExpress · Cat: HY-173032
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Catalog No: HY-173032
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
VU6033685 is the orally active positive allosteric modulator PAM for mGlu1 that positively modulates human mGlu1 and human mGlu5 with EC50 of 39 nM and 3960 nM. VU6033685 also inhibits CYP1A2, CYP2C9 and CYP2D6 with IC50 of 26, 22.3 and 23.8 ?M, respectively. VU6033685 reverses amphetamine-induced rats hyperlocomotion, protects rats from MK-801 HY-15084B -induced cognitive impairment. VU6033685 exhibits good pharmacokinetics characteristics in rats with an oral bioavailability of 42.8 %.
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