GENERAL CATALOGUE
VVD-214
HY-158116 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-158116
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Manufacturer product page
medchemexpress.com/vvd-214.htmlCatalog No: HY-158116
CAS No: 3026500-20-6
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC50 of 0.1316 AAasAasAAmuM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability MSI cancers.
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