GENERAL CATALOGUE
VVD-699
HY-173405 · 1 mg
MedChemExpress · Cat: HY-173405
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Catalog No: HY-173405
CAS No: 3055319-82-6
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
VVD-699 is a covalent RAS-PI3K inhibitor. VVD-699 covalently binds to cysteine 242 in the RAS binding domain of PI3K p110?, thereby blocking the ability of RAS to activate PI3K activity. VVD-699 is able to inhibit the growth of RAS-mutated and HER2-overexpressing tumors. VVD-699 can be used to study cancers associated with RAS mutations e.g., H358 lung cancer cells, A549 cells, FaDu cells .