GENERAL CATALOGUE
W-54011
HY-16992A · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-16992A
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Manufacturer product page
medchemexpress.com/W-54011.htmlCatalog No: HY-16992A
CAS No: 405098-33-1
Category: Immunology Inflammation
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils with a Ki value of 2.2 nM. W-54011 also inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC50s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively.
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