GENERAL CATALOGUE
WH244
HY-161410 · 500 g
MedChemExpress · Cat: HY-161410
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medchemexpress.com/wh244.htmlCatalog No: HY-161410
CAS No: 2941088-96-4
Category: Apoptosis
Pack Size: 500 g
Brand: MedChemExpress
Description
WH244 is a second generation BCL-2 and BCL-xL dual depressant PROTAC . The primary activity of WH244 is the specific degradation of BCL-2 and BCL-xL proteins BCL-xL: DC50=0.6 nM, BCL-2: DC50=7.4 nM . WH244 promotes their ubiquitination and subsequent proteasome degradation by targeting these proteins, thereby restoring the cells apoptosis pathway. WH244 has good antitumor activity. Pink: BCL-2/BCL-xL ligand HY-161415 ; Blue: E3 ligase ligand HY-112078 ; Black: linker .