GENERAL CATALOGUE
WIKI4
HY-16910 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-16910
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Catalog No: HY-16910
CAS No: 838818-26-1
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/?-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/?-catenin signaling by inhibiting the enzymatic activity of TNKS2. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 ?M.