

Z06404 · 100 ug
GenScript · Cat: Z06404
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Manufacturer product page
genscript.com/protein/Z06404-WISP1_His_Mouse.html
Description
The interplay between glioma stem cells GSCs and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma GBM , the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs M2 , and potently inhibits GBM growth. WISP1 signals through Integrin alpha6beta1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner.
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