WLBU2

Description

WLBU2 is a engineered cationic antimicrobial peptide eCAP that overcomes the environmental sensitivity of natural antimicrobial peptides AMPs . WLBU2 exhibits rapid bactericidal effect, with the MIC values of ? 10 ?M against both Gram-negative and Gram-positive bacteria including MRSA, vancomycin-resistant enterococci, K. pneumoniae, E.aerogenes, E. cloacae, Escherichia coli, et, al. WLBU2 prevents P. aeruginosa biofilm growth and retains its activity in an environment rich in mucus, low pH and high salt concentrations without negative effects on human airway epithelial cells. WLBU2 can be used for the studies of cystic fibrosis CF and Pseudomonas aeruginosa infections.