WMJ-J-09

Description

WMJ-J-09 is an HDAC inhibitor with IC50 values of 7.5 nM HDAC1 , 21.3 nM HDAC2 , 18.4 nM HDAC3 , 90.9 nM HDAC8 , 3.9 nM HDAC6 and 8715.7 nM HDAC4 . WMJ-J-09 blocks the cell cycle and induces apoptosis in cancer cells. WMJ-J-09 induces cancer cell death through the LKB1-AMPK-p38MAPK-p63-survivin signaling cascade.WMJ-J-09 inhibits HDAC enzyme activity, leading to acetylation of key proteins and thereby regulating cancer cell death. WMJ-J-09 can be used in HCT116 cells and FaDu cells research 1 2 .