GENERAL CATALOGUE
WNY0824
HY-143471 · 50 mg
MedChemExpress · Cat: HY-143471
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medchemexpress.com/wny0824.htmlCatalog No: HY-143471
CAS No: 2412707-81-2
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
WNY0824 PLK1/BRD4-IN-1 is an orally active dual inhibitor of PLK1 and BET protein families, with IC50 values of 22, 402.5, 150.7, 103.9, and 311.9 nmol/L for PLK1, BRD2, BRD3, BRD4, and BRDT, respectively. WNY0824 induces cell cycle arrest and apoptosis by inhibiting AR- and MYC-mediated transcriptional processes. In addition, WNY0824 also inhibits tumor growth in Enzalutamide HY-70002 resistant CRPC xenograft tumor models.
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