WWOX Rabbit Polyclonal Antibody

Description

EnkiLife offers the WWOX Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse species and is suitable for WB,IHC,ICC/IF,ELISA application. Alternative Names of Immunogen: WWOX; FOR; WOX1; WW domain-containing oxidoreductase; Fragile site FRA16D oxidoreductase. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:200-1:1000,ELISA 1:10000-1:20000 Background: WWOX (WW domain containing oxidoreductase) encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. WWOX spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of WWOX is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. skeletal system development,ossification,osteoblast differentiation,induction of apoptosis,steroid metabolic process,negative regulation of signal transduction,negative regulation of cell communication,regulation of cell death,positive regulation of cell death,induction of programmed cell death,regulation of Wnt receptor signaling pathway,negative regulation of Wnt receptor signaling pathway,regulation of apoptosis,positive regulation of apoptosis,regulation of programmed cell death,positive regulation of programmed cell death,skeletal system morphogenesis,oxidation reduction,bone development,