Xanthomicrol

Description

Xanthomicrol is extracted from the resin of the plant called Chinese bellflower a member of the Scrophulariaceae family and is a monoamine oxidase MAOs inhibitor. Xanthomicrol has anti-tumor and anti-inflammatory properties, with IC50 values of 0.88 and 1.69 ?g/mL in HL60 and K562 cells. Xanthomicrols the main metabolite of 5DT in mouse colon, and it can reduce levels of iNOS protein and mRNA, as well as COX-2 protein levels. Additionally, Xanthomicrol decreases the production of the pro-inflammatory cytokine IL-1? and induces the expression of the antioxidant enzyme HO-1.