GENERAL CATALOGUE
XRD-0394
HY-162472 · 5 mg
MedChemExpress · Cat: HY-162472
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medchemexpress.com/xrd-0394.htmlCatalog No: HY-162472
CAS No: 2595308-10-2
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
XRD-0394 is a potent and orally active dual ATM and DNA-PKcs inhibitor with IC50s of 0.39 nM and 0.89 nM, respectively. XRD-0394 shows selectivity over other PIKK and PI3K family members. XRD-0394 significantly enhances tumor cell killing in vitro and in vivo under therapeutic ionizing radiation conditions. XRD-0394 can potentiate the effects of PARP and topoisomerase I inhibitors in vitro.
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