Y-320

Description

Y-320 is a potent, orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Y-320 enhances TP53, DMD, and COL17A1 PTC readthrough by G418 and increases cellular protein levels and protein synthesis. Y-320 concomitants use of with a low dose of Paclitaxel HY-B0015 significantly sensitized multidrug resistance MDR tumors by inducing G2/M phase arrest and apoptosis. Y-320 can be used for research of rheumatoid arthritis RA and cancer.