GENERAL CATALOGUE
Y16
HY-12649 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-12649
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Catalog No: HY-12649
CAS No: 429653-73-6
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Y16 is a specific inhibitor of Leukemia-associated Rho guanine nucleotide exchange factor LARG with a Kd value of 76 nM. Y16 is active in blocking the interaction of LARG and related G-protein-coupled Rho GEFs with RhoA. Y16 shows no detectable effect on other diffuse B-cell lymphoma Dbl family Rho GEFs, Rho effectors, or a RhoGAP.
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