GENERAL CATALOGUE
YH-0623
HY-175454 · 50 mg
MedChemExpress · Cat: HY-175454
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Manufacturer product page
medchemexpress.com/yh-0623.htmlCatalog No: HY-175454
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
YH-0623 is an orally active mitochondrial RNA polymerase POLRMT inhibitor IC50 = 50.48 nM, Nanoluciferase Bioluminescence Resonance Energy Transfer NanoBRET assay . YH-0623 exhibits antiproliferative effects on 22Rv1 cells by reducing the expression of mitochondrial-related genes. YH-0623 inhibits 22Rv1 cell growth, colony formation, and the expression of OXPHOS-related proteins. YH-0623 significantly inhibits tumor growth in a prostate cancer xenograft mouse model. YH-0623 is indicated for prostate cancer research.
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