GENERAL CATALOGUE
YJ1206
HY-168555 · 5 mg
MedChemExpress · Cat: HY-168555
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Catalog No: HY-168555
CAS No: 3053716-98-3
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
YJ1206 is an orally active, selective CDK12/CDK13 PROTAC degrader with an IC50 of 12.55 nM for in VCaP cells. YJ1206 increases DNA damage, induces apoptosis, and promotes tumor regression in orthotopic WA74 patient-derived xenograft PDX mice models of resistant prostate cancer. YJ1206 suppresses tumor growth in vivo in conjunction with AKT pathway inhibitors. YJ1206 is composed of the CDK12/CDK13 degradation agent HY-168658 , a linker HY-W004328 , and a VHL E3 ubiquitin ligase HY-W453548 . Pink: Navitoclax; Blue: VHL ligand; Black: linker .
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