GENERAL CATALOGUE
YJ9069
HY-168556 · 5 mg
MedChemExpress · Cat: HY-168556
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medchemexpress.com/yj9069.htmlCatalog No: HY-168556
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
YJ9069 is a selective CDK12/CDK13 PROTAC degrader with an IC50 of 22.22 nM for in VCaP cells. CDK12/13 degradation rapidly triggers gene-length-dependent transcriptional elongation defects, leading to DNA damage and cell-cycle arrest. YJ9069 effectively inhibits proliferation in subsets of prostate cancer cells and significantly suppresses prostate tumor growth. Pink: CDK12/CDK13 degradation agent HY-168658 ; Black: Linker HY-W015967 ; Blue: ligand for E3 ligase HY-103596 .
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