GENERAL CATALOGUE
YKL-5-124
HY-101257 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-101257
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Manufacturer product page
medchemexpress.com/ykl-5-124.htmlCatalog No: HY-101257
CAS No: 1957203-01-8
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
YKL-5-124 is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status.
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