GENERAL CATALOGUE
YM-202074 fumarate
HY-103556 · 1 mg
MedChemExpress · Cat: HY-103556
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medchemexpress.com/ym-202074-fumarate.htmlCatalog No: HY-103556
CAS No: 299900-84-8
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
YM-202074 fumarate is a selective, allosteric metabotropic glutamate receptor type 1 mGluR1 antagonist with high affinity. YM-202074 fumarate binds to the allosteric site of rat mGluR1 with a Ki of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 8.6 nM. YM-202074 fumarate has potent neuroprotective effects in transient MCA tMCA occlusion rat models.