GENERAL CATALOGUE
YM-230888
HY-107510 · 50 mg
MedChemExpress · Cat: HY-107510
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medchemexpress.com/ym-230888.htmlCatalog No: HY-107510
CAS No: 446257-23-4
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
YM-230888 is an orally active, selective and allosteric mGlu1 receptor antagonist with a Ki of 13 nM. YM-230888 inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 13 nM. YM-230888 shows antinociceptive response in Streptozotocin HY-13753 -induced hyperalgesia models. YM-230888 significantly reduces pain parameters in complete Freunds adjuvant HY-153808 -induced arthritic pain models.