GENERAL CATALOGUE
YM-344031
HY-160998 · 50 mg
MedChemExpress · Cat: HY-160998
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Manufacturer product page
medchemexpress.com/ym-344031.htmlCatalog No: HY-160998
CAS No: 671204-98-1
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
YM-344031 is an orally active antagonist for CCR3. YM-344031 inhibits binding of Eotaxin-1 and RANTES to CCR3, with IC50 of 3.0 and 16.3 nM. YM-344031 inhibits ligand-induced rise in intracellular Ca 2+ and the ligand-induced chemotaxis. YM-344031 inhibits eotaxin-1-induced changes in eosinophil morphology in macaques blood, and prevents allergic skin reactions in a mouse allergy model.
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