GENERAL CATALOGUE
YN14-H
HY-173250 · 50 mg
MedChemExpress · Cat: HY-173250
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medchemexpress.com/yn14-h.htmlCatalog No: HY-173250
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
YN14-H is a PROTAC degrader targeting KRASG12C. YN14-H inhibits cell growth in NCI-H358 and MIA PaCa-2 cells IC50 values of 0.042, 0.021 ?M, DC50 values of 28.9, 18.1 nM, respectively . YN14-H significantly induces apoptosis and inhibits migration. YN14-H demonstrates favorable pharmacokinetic properties and excellent antitumor activity in vivo. Structure Note: Pink: target protein ligand HY-173252 ; Blue: E3 ligase ligand HY-125905 ; Black: linker HY-Y0840 ; E3 ligase ligand + linker HY-173253 .
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