GENERAL CATALOGUE
YN14
HY-155356 · 5 mg
MedChemExpress · Cat: HY-155356
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Catalog No: HY-155356
Category: GPCR G Protein
Pack Size: 5 mg
Brand: MedChemExpress
Description
YN14 is a KRASG12C proteolysis targeting chimera PROTAC . YN14 is highly potent and selective KRASG12C degrader and induces a stable KRASG12C: YN14: VHL ternary complex with low binding free energy ?G . YN14 has antiproliferative effects and significantly inhibits KRASG12C-mutant cancer cell growth. YN14 leads to tumor regression with tumor growth inhibition TGI% rates more than 100 % in the MIA PaCa-2 xenograft model.
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