GENERAL CATALOGUE
YX-02-030
HY-158684 · 1 mg
MedChemExpress · Cat: HY-158684
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medchemexpress.com/yx-02-030.htmlCatalog No: HY-158684
CAS No: 3049076-98-1
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
YX-02-030M is a PROTAC MDM2 degrader. YX-02-030M inhibits MDM2-p53 binding and VHL-HIF1? binding with IC50s of 63 nM and 1.35 ?M respectively. YX-02-030M binds MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, and effectively kills p53 mutant or deleted Triple-negative breast cancers TNBC cells. Blue: VHL ligand; Black: linker; Pink: MDM2 inhibitor .
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