(Z)-KC02

Description

Z -KC02 is an inhibitor of ABHD16A, the phosphatidylserine PS lipase that produces lyso-PS. Lysophosphatidylserine lyso-PS is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts PHARC . Z -KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. Z -KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo.