(Z)-Thiothixene-d8

Description

Z -Thiothixene-d8 NSC 108165-d8; Navan-d8; Navane-d8 is the deuterium labeled Thiothixene HY-A0139 . Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors Kis=0.417, 338, 186.2, and 363.1 nM, respectively . Thiothixene also binds to various serotonin 5-HT , histamine H1, ?1- and ?2-adrenergic, muscarinic acetylcholine, and sigma receptors Kis=15-5,754 nM as well as the dopamine, norepinephrine, and serotonin transporters Kis=3.16-30 ?M . In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.