GENERAL CATALOGUE
ZG-2291
HY-159120 · 5 mg
MedChemExpress · Cat: HY-159120
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medchemexpress.com/zg-2291.htmlCatalog No: HY-159120
CAS No: 2962103-40-6
Category: Metabolic Enzyme Protease
Pack Size: 5 mg
Brand: MedChemExpress
Description
ZG-2291 is a selective inhibitor targeting FIH Factor Inhibiting HIF with oral activity. By binding to FIH, ZG-2291 promotes a conformational flip of a catalytically important tyrosine, enabling selective inhibition of FIH without affecting other 2OG oxygenases in the JmjC subfamily. ZG-2291k enhances thermogenesis in ob/ob mice and improves obesity-related symptoms and metabolic dysfunctions. ZG-2291 holds promise for research in the field of obesity-related diseases.
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