GENERAL CATALOGUE
ZINC05007751
HY-122639 · 5 mg
MedChemExpress · Cat: HY-122639
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medchemexpress.com/zinc05007751.htmlCatalog No: HY-122639
CAS No: 591239-68-8
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 ?M. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9.