GENERAL CATALOGUE
ZnPc-O3-JQ1
HY-176724 · 50 mg
MedChemExpress · Cat: HY-176724
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medchemexpress.com/znpc-o3-jq1.htmlCatalog No: HY-176724
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
ZnPc-O3-JQ1 is a light-triggered BRD4 degrader. Under illumination, ZnPc-O3-JQ1 generates reactive oxygen species ROS that degrades BRD4. The degradation of BRD4 results in downregulation of HIF-1?, thereby counteracting the photodynamic therapy PDT resistance induced by tumor hypoxia. ZnPc-O3-JQ1 exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 consists of three parts: BRD4 ligand HY-78695 ; Linker HY-W040165 ; Photosensitizer HY-176725 .
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