GENERAL CATALOGUE
ZSH-2117
HY-174415 · 50 mg
MedChemExpress · Cat: HY-174415
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Manufacturer product page
medchemexpress.com/zsh-2117.htmlCatalog No: HY-174415
Category: JAK STAT Signaling
Pack Size: 50 mg
Brand: MedChemExpress
Description
ZSH-2117 is a covalent and selective EGFR PROTAC degrader with a DC50 of 45 nM in Ba/F3-EGFRL858R/T790M/C797S cells. ZSH-2117 significantly inhibits cell proliferation and reduces the downstream EGFR signaling proteins level of AKT and ERK. ZSH-2117 effectively inhibits tumor growth in Ba/F3-EGFRL858R/T790M/C797S xenograft mice model. Pink: EGFR ligand HY-175162 ; Blue: NEDD4 ligase ligand HY-175159 ; Black: linker
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