GENERAL CATALOGUE
ZX-29
HY-135887 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-135887
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medchemexpress.com/zx-29.htmlCatalog No: HY-135887
CAS No: 2254805-62-2
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
ZX-29 is a potent and selective ALK inhibitor with an IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum ER stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect.
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